Diabetes and Obesity

Predisposition to tract infections (UTIs) in diabetes mellitus (DM) results from several factors. Susceptibility increases with longer period and greater severity of diabetes. High urine glucose content and defective host immune factors Leads to infection. Hyperglycemia causes neutrophil dysfunction which increasing in intracellular calcium levels and interfering with actin and, thus, diapedesis and phagocytosis. Vaginal candidiasis and vascular disease also play aKey role in recurrent infections.